Robert Oostendorp
Robert A.J. Oostendorp
Associate Professor, Habilitation in Experimental Hematology,
Technical University of Munich, Munich, Germany
Education
2013 Associate Professor
2006 Assistant Professor; Habilitation in Experimental Hematology, Technical University of Munich, Munich, Germany
1992 PhD (Dr.), “Vrije Universiteit”, Amsterdam, the Netherlands
1987-1992 PhD research at the Institute of Pathology, “Vrije Universiteit,” Amsterdam, the Netherlands
1985-1987 Master Study of Farmacochemistry (main subject: Molecular Toxicology), “Vrije Universiteit,” Amsterdam, the Netherlands
1981-1984 Bachelor Study of Chemistry, “Vrije Universiteit,” Amsterdam, the Netherlands
Job experience
Since 2014 Speaker of the DFG Research Unit: FOR 2033: The Hematopoietic Niches Since
2003 Group Leader (Laboratory of Stem Cell Physiology), 3rd Department of Internal Medicine, Klinikum rechts der Isar, Technical University Munich, Germany
2000-2003 Senior postdoctoral Research at the Technical University of Munich, Klinikum rechts der Isar, Clinic of Internal Medicine III, Munich, Germany (Director: Prof. Christian Peschel)
1998-2000 Senior Postdoctoral research at the Department of Cell Biology and Genetics, Erasmus University, Rotterdam, the Netherlands (Supervision: Elaine Dzierzak)
1998 Senior Postdoctoral research, Institute of Experimental Hematology, Helmholtz Center, Munich, Germany
1996-1998 Postdoctoral research at the Terry Fox laboratory, British Columbia cancer Agency, Vancouver, Canada (Supervision: Connie J Eaves)
1992-1996 Postdoctoral research at the Institute of Experimental Hematology, Helmholtz Center, Munich, Germany (Supervision: Prof. Hans-Günther Mergenthaler)
1987-1992 Research Assistant (O.I.O.), Vrije Universiteit Amsterdam, Institute of Pathology, Amsterdam, The Netherlands (Supervision: Prof. Rik J. Scheper)
1984 Animal caretaker, Vrije Universiteit Amsterdam, Institute of Pathology, Amsterdam, The Netherlands (Supervision: Prof. Rik J. Scheper)
10 Most important Publications (chronologous, newest first)
1. Kreutmair S, Erlacher M, Andrieux G, Istvanffy R, Mueller-Rudorf A, Zwick M, Rückert T, Pantic M, Poggio T, Shoumariyeh K, Mueller TA, Kawaguchi H, Follo M, Klingeberg C, Wlodarski M, Baumann I, Pfeifer D, Kulinski M, Rudelius M, Lemeer S, Kuster B, Dierks C, Peschel C, Cabezas-Wallscheid N, Duque-Afonso J, Zeiser R, Cleary ML, Schindler D, Schmitt-Graeff A, Boerries M, Niemeyer CM, Oostendorp RAJ, Duyster J, Illert AL. Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure. J Clin Invest. 2020; 130: 2827-2844. doi: 10.1172/JCI126215.
2. Mende N, Jolly A, Percin GI, Günther M, Rostovskaya M, Krishnan SM, Oostendorp RAJ, Dahl A, Anastassiadis K, Höfer T, Waskow C. Prospective isolation of nonhematopoietic cells of the niche and their differential molecular interactions with HSCs. Blood. 2019; 134: 1214-1226. doi: 10.1182/blood.2019000176
3. Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RAJ. Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. J Exp Med. 2017; 214: 165-181. doi: 10.1084/jem.20151414.
4. Ruf F, Schreck C, Wagner A, Grziwok S, Pagel C, Romero S, Kieslinger M, Shimono A, Peschel C, Götze KS, Istvanffy R*, Oostendorp RAJ*. Loss of Sfrp2 in the niche amplifies stress-induced cellular responses, and impairs the in vivo regeneration of the hematopoietic stem cell pool. Stem Cells. 2016; 34: 2381-92. doi: 10.1002/stem.2416. (*: joint senior authors)
5. Istvánffy R, Vilne B, Schreck C, Ruf F, Pagel C, Grziwok S, Henkel L, Prazeres da Costa O, Berndt J, Stümpflen V, Götze KS, Schiemann M, Peschel C, Mewes HW, Oostendorp RAJ. Stroma-derived connective tissue growth Factor maintains cell cycle progression and repopulation activity of hematopoietic stem cells in vitro. Stem Cell Reports. 2015; 5: 702-715. doi: 10.1016/ j.stemcr.2015.09.018.
6. Wöhrer S, Knapp DJ, Copley MR, Benz C, Kent DG, Rowe K, Babovic S, Mader H, Oostendorp RAJ, Eaves CJ. Distinct Stromal Cell Factor Combinations Can Separately Control Hematopoietic Stem Cell Survival, Proliferation, and Self-Renewal. Cell Rep. 2014;
7: 1956-67. doi: 10.1016/j.celrep.2014.05.014. 7. Florian MC, Nattamai KJ, Dörr K, Marka G, Uberle B, Vas V, Eckl C, Andrä I, Schiemann M, Oostendorp RAJ, Scharffetter-Kochanek K, Kestler HA, Zheng Y, Geiger H. A canonical to noncanonical signalling switch in haematopoietic stem-cell ageing. Nature. 2013; 503: 392-6. doi: 10.1038/nature12631
8. Lutzny G, Kocher T, Schmidt-Supprian M, Rudelius M, Klein-Hitpass L, Finch AJ, Dürig J, Wagner M, Haferlach C, Kohlmann A, Schnittger S, Seifert M, Wanninger S, Zaborsky N, Oostendorp R, Ruland J, Leitges M, Kuhnt T, Schäfer Y, Lampl B, Peschel C, Egle A, Ringshausen I. Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo. Cancer Cell. 2013; 23: 77-92. doi: 10.1016/j.ccr.2012.12.003
9. Istvanffy R, Kröger M, Eckl C, Gitzelmann S, Vilne B, Bock F, Graf S, Schiemann M, Keller UB, Peschel C, Oostendorp RAJ. Stromal pleiotrophin regulates repopulation behavior of hematopoietic stem cells. Blood. 2011; 118: 2712-22. doi: 10.1182/blood-2010-05-287235.
10. Renström J, Istvanffy R, Gauthier K, Shimono A, Mages J, Jardon-Alvarez A, Kröger M, Schiemann M, Busch DH, Esposito I, Lang R, Peschel C, Oostendorp RAJ. Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells. Cell Stem Cell. 2009; 5: 157-67. doi: 10.1016/j.stem.2009.05.020
